Why Didn’t My Cortisone Shot Work in My Knee? When Cortisone Fails

Cortisone shot for knee

Cortisone shots, widely known for their anti-inflammatory properties, have been the go-to for many experiencing knee pain. However, for some, these injections don’t provide the relief they hoped for. If this happened to you, you may be wondering why didn’t my cortisone shot work in my knee?

Many reasons, from the severity of your injury to your body’s unique response, can influence cortisone’s efficacy. When cortisone disappoints, many patients are left wondering about alternative treatments. If you’re in this situation, don’t worry, we’re also going to cover one of the most effective, research-backed alternatives to cortisone shots for pain and inflammation.

Let’s examine why cortisone might fail and how alternative therapies like stem cell therapy can be your next step forward.


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Why Didn’t My Cortisone Shot Work in My Knee?

Cortisone shots are often utilized to reduce inflammation and relieve pain, but they might not always work as expected for everyone. Here are several reasons why a cortisone shot might not offer relief from knee pain and swelling:

Severity of Damage

Cortisone is most effective for inflammation-related pain. If the knee pain stems from structural damage like severe osteoarthritis or a torn ligament, cortisone might not be as effective.

Accuracy of Injection

The effectiveness of the cortisone shot largely depends on the accurate placement of the injection. If the cortisone doesn't reach the inflamed area, it might not provide the desired relief.

Individual Variation

Each individual’s body can respond differently to treatments. Some might metabolize or disperse the cortisone faster, reducing its effectiveness.

Frequency of Injections

Repeated cortisone injections in a short time can diminish its effectiveness. Over time, the body might become resistant or less responsive to the medication.

Type of Corticosteroid Used

There are different types of corticosteroids, and the one chosen might not be the most effective for a particular individual's condition.

Presence of Other Medical Conditions

Conditions like diabetes or certain types of infections can interfere with the efficacy of the cortisone injection.

Underlying Causes Not Addressed

While cortisone can provide temporary relief, it doesn’t address the root causes of knee pain, like poor posture, muscle imbalances, or inappropriate footwear.

Exploring alternative treatments is essential for those who find themselves wondering why didn’t my cortisone shot work in my knee?

Apart from traditional treatments, therapies like stem cell injections are gaining traction. Stem cells can repair damaged tissue, making them a possible solution for those looking for more than symptomatic relief.

However, consulting with a healthcare professional before deciding on the best course of action is essential.

The Downside of Cortisone Shots

While beneficial for many in the short term, Cortisone shots come with potential long-term downsides that patients should be aware of. One of the significant concerns is the potential for cortisone to damage cartilage. Ironically, cortisone injections are frequently prescribed to combat inflammation often caused by damage to the cartilage itself. Over-relying on these injections can exacerbate the issue they’re intended to treat, accelerating cartilage degradation and potentially leading to further joint problems.

Repeated injections can also weaken your surrounding ligaments and tendons, making your joint more susceptible to injuries. There’s also the risk of introducing infections into your joint, especially if not administered under sterile conditions. Some patients might experience side effects, including skin discoloration at the injection site or a rise in blood sugar levels, particularly concerning diabetics. While cortisone shots can offer immediate relief, weighing these benefits against the potential long-term repercussions is vital.

The good news is you can always try alternative or complementary treatments to protect joint health.

The Advanced Alternative to Cortisone Shots for Knee Pain

Stem cell therapy is emerging as a transformative solution in medical treatments for inflammation and joint pain. This therapy is known for harnessing your body’s intrinsic healing mechanisms.Stem cells can evolve into specialized cells, potentially aiding in the repair and regeneration of damaged tissues, including cartilage. This is especially significant considering the concerns around cortisone shots, which, despite their short-term relief, might lead to cartilage degradation in the long run.

Stem cell therapy also presents fewer side effects than cortisone, preventing typical issues like skin discoloration or a spike in blood sugar levels.

A 2020 study published in Medicine (Baltimore) demonstrated that patients undergoing stem cell therapy experienced improved pain scores and knee functionality up to 24 months compared to control groups. Stem cell therapy presented itself as a more effective solution than traditional treatments for knee osteoarthritis, offering notable pain relief without additional side effects.

Another 2020 research article published in the Yeungnam Univ J Med delves into the potential of stem cells as an emerging solution for knee pain, given their impressive ability to modify osteoarthritis and their potential to generate cartilage. These stem cells can differentiate into connective tissues, including bone, cartilage, and muscles.

So, stem cell therapy offers hope and a more natural, holistic approach to healing and inflammation reduction for those wondering why didn’t my cortisone shot work in my knee? And for those wary of the long-term repercussions of cortisone shots.

Contact GIOSTAR Chicago Today for Stem Cell Therapy for Your Knee

At GIOSTAR Chicago, our commitment to excellence sets us apart in regenerative medicine. With a team composed of globally recognized researchers and experts, we’ve consistently been at the cutting edge of groundbreaking stem cell research and treatments. Our rich legacy and deep-rooted foundation in the field enable us to offer the highest standards of care, ensuring our patients receive the most advanced and effective treatments available.

Beyond our technical expertise, our personalized approach means we prioritize your unique needs and concerns, working closely with you to devise a tailored treatment plan. By choosing GIOSTAR Chicago, you’re not just selecting a treatment but a dedicated partner in your journey toward optimal health.

Contact us today by completing this form or calling us at 844 446 7827 to learn more about our stem cell therapy and how it can help you with your knee pain.

About GIOSTAR Chicago:

GIOSTAR Chicago is dedicated to developing the most advanced stem cell-based technologies and providing the best regenerative medicine for people who want to enjoy a healthy and active lifestyle.

Written by Shelly Sood

Shelly Sood is an author, founder, and partner at GIOSTAR Chicago. She's passionate about advancing the science related to regenerative medicine and making treatment accessible to the masses. Her team consists of world-renowned authorities in stem cell biology, protein biochemistry, molecular biology, immunology, in utero transplantation of stem cell, tissue targeting, gene therapy and clinical research. Stay tuned to for more of Shelly's updates regarding lifestyle, stem cell research and application, and more.