Low Platelets and Cirrhosis: What’s the Connection?

low platelets and cirrhosis

Cirrhosis is a serious condition that can have many complications, including low platelet count, or thrombocytopenia. Platelets play a critical role in blood clotting, and a decrease in their number can lead to issues such as bleeding and bruising. In this article, we will explore the connection between low platelets and cirrhosis, including the factors that contribute to thrombocytopenia in individuals with cirrhosis. 

The Connection Between Low Platelets & Cirrhosis

Cirrhosis is a condition characterized by the progressive scarring of the liver, which impairs its normal function and blood flow through the organ. As a result, cirrhosis can lead to various complications, one of which is a decrease in platelet count, known as thrombocytopenia. Several factors contribute to this phenomenon:

Portal hypertension

Cirrhosis leads to increased resistance to blood flow in the liver, causing blood to back up in the portal vein, which carries blood from the gastrointestinal tract and spleen to the liver. This increased pressure in the portal vein is known as portal hypertension. Portal hypertension can lead to the formation of enlarged blood vessels (varices) in the esophagus and stomach, which are prone to rupture and bleeding. As a result, platelets are used up in the clotting process to control bleeding, leading to a reduction in their circulating numbers.

Splenic sequestration

In cirrhosis, the spleen often becomes enlarged (splenomegaly). The enlarged spleen can trap platelets, leading to their sequestration and decreased availability in the bloodstream.

Decreased production

The liver is a vital organ involved in the production of various substances, including proteins responsible for blood clotting factors. In cirrhosis, the liver's ability to produce these clotting factors is compromised, leading to reduced platelet production and overall clotting dysfunction.


The spleen can become overactive in cirrhosis due to portal hypertension and congestion. This condition is known as hypersplenism, and it can lead to the premature destruction of platelets, further contributing to thrombocytopenia.

Thrombocytopenia in cirrhosis can lead to an increased risk of bleeding and bruising, even with minor injuries. It is essential for individuals with cirrhosis to be closely monitored by their healthcare providers, as severe thrombocytopenia can be life-threatening in certain situations.


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Stem Cell Therapy for Cirrhosis

While most treatments today focus on medications that simply help patients manage the effects of cirrhosis – stem cell therapy aims to take things further by actually helping the liver to regenerate itself. 

Stem cell therapy has emerged as a potential treatment option for liver disease, with promising outcomes in several studies. Stem cells are undifferentiated cells that can differentiate into various cell types, including liver cells. They can also secrete growth factors and other molecules that promote tissue repair and regeneration.

In one study, researchers used mesenchymal stem cells (MSCs) to treat individuals with cirrhosis. The researchers found that MSCs improved liver function and reduced portal hypertension. Another study found that using bone marrow-derived stem cells improved liver function and reduced fibrosis in individuals with cirrhosis.

At GIOSTAR Chicago, we offer stem cell therapy to patients with liver disease who are looking for a second chance – and are open to alternative treatments that aim to assist the body’s innate healing mechanisms. For more information on our stem cell treatments for liver disease, tap or click here. 

low platelets and cirrhosis

GIOSTAR Chicago: A Leader in Stem Cell Therapy

If you or a loved one has low platelets from cirrhosis and is interested in exploring stem cell therapy as a treatment option, you’ll be happy to know that GIOSTAR Chicago is a world-leading provider of stem cell therapy.

Our proprietary protocols have been developed through years of research and clinical practice, and have helped thousands of patients around the world. We pride ourselves on staying at the forefront of stem cell therapy research and application, ensuring that our patients receive the most advanced treatments available. Our team of medical experts will work closely with you to develop a personalized treatment plan that meets your unique needs and goals.

Get Your Free Consultation By Reaching Out Today

If you or a loved one is suffering with cirrhosis and low platelets, it is important to explore all available treatment options. Fill out the form to contact GIOSTAR Chicago today or call (844) 446-7827 to discuss your condition and learn more about how stem cell therapy may be able to help you. Our team of medical professionals can provide personalized treatment recommendations and answer any questions you may have. Remember, taking proactive steps towards your health can make all the difference in your quality of life.

About GIOSTAR Chicago:

GIOSTAR Chicago is dedicated to developing the most advanced stem cell-based technologies and providing the best regenerative medicine for people who want to enjoy a healthy and active lifestyle.

Written by Shelly Sood

Shelly Sood is an author, founder, and partner at GIOSTAR Chicago. She's passionate about advancing the science related to regenerative medicine and making treatment accessible to the masses. Her team consists of world-renowned authorities in stem cell biology, protein biochemistry, molecular biology, immunology, in utero transplantation of stem cell, tissue targeting, gene therapy and clinical research. Stay tuned to for more of Shelly's updates regarding lifestyle, stem cell research and application, and more.