Dr. Anand Srivastava: Scientific Achievements
- Srivastava developed the animal material free and serum-free Human Embryonic Stem (ES) cell culture condition to use Human ES cells to treat human diseases.
- Dr. Srivastava for the first time showed that if ES cells injected into developing fetuses in utero participate in development of all body of a living organism.
- For the first time, he showed that ES cells are better accepted by the transplanted animals in comparison to adult stem cells.
- For the first time, he showed the way to generate a high number of pre-erythrocytes using glucocorticoid hormone; this may be used to treat several blood diseases.
- For the first time, using ES cells he generated a high number of CD34+ expressing a kind of hematopoietic stem cell which can be used to treat several autoimmune diseases, immune reconstitution and blood diseases.
- For the first time, he showed the molecular mechanism behind the regulation of ES cell differentiation into hematopoietic cells.
- For the first time, he showed that ES cells automatically recognize the damaged portion of the brain, and can be used to repair the damaged brain.
- For the first time, he showed that ES cell can be used to treat Crohn’s disease (an inflammatory bowel disease that may develop into colon cancer).
- For the first time, he demonstrated that mammalian fetuses can be programmed inside the mother’s uterus to face the challenges of future possible infection. This finding is very important in the development of advanced therapy for cancer, AIDS, and many other fatal diseases. Utilizing these techniques, fetuses can be given information about all possible infections, providing the capability to counter those infections and diseases.
- He has demonstrated for the first time that it is easy to correct the genetic diseases in developing fetus in utero in comparison to adult animals.
- He has shown for the first time that the lung cancer cells can be treated with the help of plant product curcumin, and can be used as an effective cancer therapeutic agent. He also demonstrated that how curcumin regulated the genes related to programmed death of cancerous cell – a finding that will aid in the development of non-toxic, less expensive, easily available drug for cancer.
- The biggest problem in the treatment of cancer and other diseases is the non-specific distribution of medicine and toxic chemotherapeutic agents to healthy tissues. Dr. Srivastava for the first time developed a technique that can help in targeting diseased tissues using the tissue receptor binding peptide ligands. These techniques can be used for targeted delivery of drugs and genes (in case of genetic disease) to the specific fetal tissues inside the mother uterus, without harming the normal tissues of mother and fetus.
- For the first time, he demonstrated the insertion of foreign pancreas enzyme specific gene promoter into developing animals embryos, and successfully showed the incorporation and regulation of pancreatic enzymes in the control of the inserted gene. This is a very important finding and proves that the defective genes can be replaced easily and effectively by the normal functional genes during the development of animals. This finding will help in the change of defective genes of insulin hormone, which is present in the pancreas of patients suffering from diabetes and many other genetic diseases.
- For the first time, he reported the gene sequence of all important pancreatic enzymes (three isoforms of trypsinogen, two isoforms of chymotrypsinogen, four types of elastases, three forms of carboxypeptidases and lipase) and its evolutionary relationship with the human. Also, he reported first time the regulation of digestion by these enzymes in the alimentary canal during digestion of proteins in the developing animals.
- For the first time, he cloned and sequenced two types of human homologs of the Vitamin D receptor gene from Japanese flounder. This is the most important receptor, which helps in the development of bone. Before Dr. Srivastava’s report, characteristics of this gene were not known in Japanese flounder. This finding helped in the understanding of the genetic evolution of mammals.
- For the first time, he cloned and sequenced the homolog of human placental protein, PP11, and mouse T cell-specific, Tcl-30, in the pancreas of Japanese flounder. This study suggests that these genes evolved from the fish pancreas and in fish they help in synthesizing the digestive enzymes. During their evolution, however, their function got changed, causing them to work differently in the mammalian placenta. This was a very important finding related to this rare gene.
- For the first time, he has shown that the Hox and sonic hedgehog genes regulate the development of bones and respiratory organs. He also demonstrated that these genes could be regulated artificially. This was a very important finding, since it provides insights into how genes regulate the development of organs.
- For the first time, he purified and characterized the human homologs of AAT and ASPT enzymes. These are the basic clinical marker in all infection, and the major marker of liver function test.
- For the first time, he demonstrated the coordination of AAT and ASPT enzymes in the production of energy through amino acids after aerobic respiration.
- For the first time, he has shown that according to the metabolic demand of the body AAT and ASPT genes synthesized additional forms of its isoform to cope up with the extra energy demand and work as an “on” and off” switch.
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